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Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

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Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
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Assessment of the Cardiovascular System I: Subjective Data01:23

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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
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Updated: Jun 24, 2025

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Assessment of Chemotherapy-Induced Cardiac Dysfunction in Breast Cancer Patients: A Prospective Study.

Jasvinder Singh1, Syed Abid Iqbal2, Sahini Gajula3

  • 1Cardiology and Electrophysiology, Asian Institute of Gastroenterology (AIG) Hospital, Hyderabad, IND.

Cureus
|June 3, 2024
PubMed
Summary

Chemotherapy can cause heart problems, but early detection and treatment improve recovery. Acute cardiotoxicity in breast cancer patients is manageable with timely interventions.

Keywords:
acute cardio toxicitychemotherapy-related cardiac dysfunction (ctrcd)global longitudinal strain (gls)heart failure (hf)left ventricular dysfunction (lvd)

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Area of Science:

  • Cardiology
  • Oncology
  • Pharmacology

Background:

  • Cancer therapies improve survival but increase treatment-related side effects.
  • Acute cardiac toxicity from chemotherapy lacks sufficient predictive literature.
  • Cardiovascular complications, particularly cardiac dysfunction, are significant concerns in breast cancer patients undergoing therapy.

Purpose of the Study:

  • To evaluate the incidence, timing, and clinical factors of chemotherapy-related cardiac dysfunction (CTRCD) in breast cancer patients.
  • To assess global longitudinal strain (GLS) and response to heart failure (HF) therapy in patients with cardiotoxicity.
  • To emphasize therapy-related cardiac dysfunction in breast cancer treatment.

Main Methods:

  • Prospective observational study of 97 breast cancer patients from March 2020 to October 2021.
  • Assessment of left ventricular ejection fraction (LVEF) at baseline, mid-, and post-chemotherapy.
  • Modification of chemotherapy and initiation of HF therapy for patients developing left ventricular dysfunction (LVD).

Main Results:

  • Chemotherapy-related cardiac dysfunction (CTRCD) occurred in 13.4% of patients (13/97).
  • Higher risk of LVD was associated with ER+, PR+, HER2+ status and cancer stages III-IV.
  • Among affected patients, 77% had complete cardiac recovery; partial recovery was linked to advanced cancer stages and lower treatment intensity.

Conclusions:

  • Acute cardiotoxicity is not directly correlated with cumulative anthracycline dosage.
  • Early detection of CTRCD, chemotherapy regimen adjustment, and prompt HF therapy significantly improve cardiac function recovery.