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Related Experiment Video

Updated: Apr 29, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Successful Collagen Crosslinking in a Patient With Keratoconus and Systemic Scleroderma.

Ayman Alghamdi1, Essam A Alghamdi2, Abdullah Alghamdi3

  • 1Oculoplastic Division, King Khaled Eye Specialist Hospital, Riyadh, SAU.

Cureus
|June 3, 2024
PubMed
Summary

Scleroderma patients with keratoconus (KC) can safely undergo corneal collagen cross-linking (CXL). This study shows CXL is a viable treatment option for KC in patients with scleroderma, offering hope for improved vision.

Keywords:
case reportcollagen cross linkingcollagen vascular diseaseconnective tissue disordercontact lens wearcorneal ectasiakeratoconuskeratoconus progression

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Scleroderma is an autoimmune connective tissue disease.
  • Keratoconus (KC) is a rare condition that can co-occur with scleroderma.
  • Contact lenses, vital for KC, pose challenges for scleroderma patients due to physical limitations.

Observation:

  • Corneal collagen cross-linking (CXL) is essential for progressive KC to prevent vision loss.
  • Concerns exist regarding potential complications like corneal melt after CXL in scleroderma patients.
  • A case involving a patient with both KC and scleroderma undergoing CXL was analyzed.

Findings:

  • The patient with keratoconus and scleroderma successfully underwent corneal collagen cross-linking (CXL).
  • No adverse events, such as corneal melt or delayed healing, were observed post-procedure.
  • This case demonstrates the safety and efficacy of CXL in this specific patient population.

Implications:

  • Corneal collagen cross-linking (CXL) appears to be a safe and effective treatment for keratoconus (KC) even in patients with co-existing scleroderma.
  • This finding may encourage the use of CXL in similar cases, potentially improving visual outcomes.
  • Further research is warranted to confirm these findings in a larger cohort of patients.