Related Experiment Video

Updated: Jun 24, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

Histoplasmosis Causing Overt Inflammation Presenting as Pericarditis: A Case Report

Amanda C Yeates1, David S Quimby2

  • 1Infectious Diseases, Creighton University, Omaha, USA.

Cureus
|June 3, 2024
PubMed

Insights

Histoplasma capsulatum can cause varied symptoms, including pericarditis, especially in immunocompromised individuals. This case highlights a rare presentation in a healthy young male with a strong inflammatory response.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Histoplasma capsulatum commonly causes pulmonary infections.
  • The fungus employs virulence factors to evade host immunity, particularly in immunosuppressed individuals.
  • Pericarditis is a recognized, yet challenging, manifestation of histoplasmosis.

Observation:

  • A case study of a healthy young male is presented.
  • The patient developed pericarditis.
  • A robust inflammatory response to Histoplasma capsulatum infection was observed.

Findings:

  • Histoplasmosis can manifest as pericarditis even in healthy hosts.
  • A strong inflammatory response can lead to cardiac complications.
  • Diagnosis and treatment of histoplasmosis-induced pericarditis can be complex.

Implications:

  • This case expands the understanding of Histoplasma capsulatum's clinical spectrum.
  • It emphasizes the importance of considering fungal infections in unexplained pericarditis.
  • Further research into host-pathogen interactions in histoplasmosis is warranted.
Keywords:
fungal infectionhistoplasmosisinflammationinflammatory syndromepericarditis

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.2K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

630

Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
316
Inflammation01:38

Inflammation

Overview
53.3K
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
216
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.1K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
259
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
165