Case Report: Micafungin for treating Candida glabrata urinary infection: a clinical case in a premature neonate

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Carlos Javier Parramon-Teixido1, Carme Garcia Esquerda1, Marie Antoinette Frick2

  • 1Department of Pharmacy, Vall d'Hebron University Hospital, Barcelona, Spain.

Frontiers in Pediatrics
|June 3, 2024
PubMed

Insights

Fungal urinary tract infections (UTIs) are increasing in premature newborns. Micafungin shows promise as a safe and effective treatment for Candida glabrata UTIs in extremely premature infants.

Area of Science:

  • Neonatal intensive care
  • Infectious diseases
  • Mycology

Background:

  • Urinary tract infections (UTIs) in premature newborns (PNBs) are a significant concern in neonatal intensive care units (NICUs).
  • Broad-spectrum antibiotic use has led to a rise in fungal UTIs, particularly non-albicans Candida species.
  • Diagnosis requires culturing Candida spp. from urine, especially critical in very low birth weight (VLBW) PNBs due to invasive candidiasis risks.

Observation:

  • An extremely premature newborn (EPNB) developed a UTI caused by Candida glabrata.
  • The EPNB required treatment for this challenging fungal infection.

Findings:

  • The EPNB was successfully treated with micafungin.
  • This case demonstrates micafungin's potential efficacy in treating Candida glabrata UTIs in neonates.

Implications:

  • Micafungin may be a viable alternative treatment for fungal UTIs in premature infants.
  • Further research is warranted to establish micafungin's role in neonatal fungal infections.
  • Improved diagnostic and treatment strategies are needed for fungal UTIs in vulnerable PNB populations.

Keywords:
Candida glabratacase reportmicafunginpremature infanturinary tract infection

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