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Published on: September 15, 2018
Identifying the differentially expressed peripheral blood microRNAs in psychiatric disorders: a systematic review and
Xiaoyan Liu1, Liying Dong2, Zhaowei Jiang2
1Department of Psychiatry, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background:
Evidence has suggested that microRNAs (miRNAs) may play an important role in the pathogenesis of psychiatric disorders (PDs), but the results remain inconclusive. We aimed to identify specific differentially expressed miRNAs and their overlapping miRNA expression profiles in schizophrenia (SZ), major depression disorder (MDD), and bipolar disorder (BD), the three major PDs.
Methods:
The literatures up to September 30, 2023 related to peripheral blood miRNAs and PDs were searched and screened from multiple databases. The differences in miRNA levels between groups were illustrated by the standardized mean difference (SMD) and 95% confidence interval (95% CI).
Results:
In total, 30 peripheral blood miRNAs were included in the meta-analysis, including 16 for SZ, 12 for MDD, and 2 for BD, each was reported in more than 3 independent studies. Compared with the control group, miR-181b-5p, miR-34a-5p, miR-195-5p, miR-30e-5p, miR-7-5p, miR-132-3p, miR-212-3p, miR-206, miR-92a-3p and miR-137-3p were upregulated in SZ, while miR-134-5p, miR-107 and miR-99b-5p were downregulated. In MDD, miR-124-3p, miR-132-3p, miR-139-5p, miR-182-5p, miR-221-3p, miR-34a-5p and miR-93-5p were upregulated, while miR-144-5p and miR-135a-5p were downregulated. However, we failed to identify statistically differentially expressed miRNAs in BD. Interestingly, miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD.
Conclusions:
Our study identified 13 differentially expressed miRNAs in SZ and 9 in MDD, among which miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD by systematically analyzing qualified studies. These miRNAs may be used as potential biomarkers for the diagnosis of SZ and MDD in the future.
Systematic Review Registration:
http://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486982.
Insights
MicroRNAs (miRNAs) are implicated in psychiatric disorders. This study identified specific differentially expressed miRNAs in schizophrenia and major depressive disorder, with miR-132-3p and miR-34a-5p found in both conditions.
Area of Science:
- Neuroscience
- Genetics
- Biochemistry
Background:
- MicroRNAs (miRNAs) are increasingly recognized for their potential role in the pathogenesis of psychiatric disorders (PDs).
- Previous research on miRNA expression profiles in PDs has yielded inconclusive results.
- Identifying specific differentially expressed miRNAs is crucial for understanding disease mechanisms.
Conclusions:
- This meta-analysis identified 13 differentially expressed miRNAs in SZ and 9 in MDD.
- miR-132-3p and miR-34a-5p were consistently upregulated in both schizophrenia and major depressive disorder.
- These specific miRNAs show promise as potential diagnostic biomarkers for SZ and MDD in the future.
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