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Successful post-incomplete resection management of gastrointestinal stromal tumor using imatinib based on adenosine
In-Sun Woo1, Young-Rok Kim1, Sang-Won Kim1
1KU Animal Cancer Center, Konkuk University Veterinary Medical Teaching Hospital, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea (Woo, Y-R Kim, S-W Kim, Choi, H-Y Yoon, Bae, K-A Yoon, J-H Kim); Department of Veterinary Internal Medicine (Woo, Y-R Kim, S-W Kim, J-H Kim) and Department of Veterinary Surgery (Choi, H-Y Yoon) and Department of Veterinary Biochemistry (Bae, K-A Yoon), College of Veterinary Medicine, Konkuk University, No. 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib. Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor. Key clinical message: Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic drugs for incompletely resected gastrointestinal stromal tumors in dogs.
Gastrointestinal stromal tumors arising from gastric cardia are uncommon in dogs. A few studies have shown the effectiveness of tyrosine kinase inhibitors in the treatment of canine gastrointestinal stromal tumors, but no standardized protocols are currently available. An 11-year-old spayed female Maltese dog was diagnosed with a gastrointestinal stromal tumor using histopathological and immunohistochemical analyses. An adenosine triphosphate-based tumor chemosensitivity assay revealed that imatinib at lower concentrations had a stronger inhibitory effect than toceranib. Based on the results of the assay, the dog was treated with imatinib after surgery. After 28 mo of therapy, there was no recurrence of the tumor. Key clinical message: Adenosine triphosphate-based tumor chemosensitivity assays may help clinicians to select appropriate postoperative chemotherapeutic drugs for incompletely resected gastrointestinal stromal tumors in dogs.
