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Related Experiment Videos

Vasoactive intestinal polypeptide nerves in human upper respiratory tract.

R Uddman, F Sundler

    ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
    |January 1, 1979
    PubMed
    Summary

    Vasoactive intestinal polypeptide (VIP) nerves are found in the human upper respiratory tract, particularly the nose and trachea. These nerves may represent a distinct component of the autonomic nervous system.

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    Area of Science:

    • Neuroscience
    • Anatomy
    • Physiology

    Background:

    • Vasoactive intestinal polypeptide (VIP) is a neuropeptide with potential neurotransmitter functions.
    • The distribution and role of VIP in the human upper respiratory tract are not well-established.

    Purpose of the Study:

    • To investigate the presence and distribution of VIP-immunoreactive nerves in the human upper respiratory tract.
    • To determine the origin of VIP nerves in the trachea.

    Main Methods:

    • Immunohistochemistry was used to detect VIP-immunoreactive nerves.
    • Tissue samples from the human nose and trachea were analyzed.

    Main Results:

    • VIP nerves were abundant in the inferior turbinate of the nose and the tracheal wall.

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  • These nerves were located in subepithelial connective tissue, around blood vessels and glands, and in tracheal smooth muscle.
  • VIP-immunoreactive nerve cell bodies were exclusively found in the tracheal wall.

    • Conclusions:

    • VIP nerves are a significant component of the human upper respiratory tract innervation.
    • The findings suggest a local origin for tracheal VIP nerves.
    • VIP-containing nerves may represent a distinct functional division of the autonomic nervous system, separate from adrenergic and cholinergic systems.