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Aseptic Laboratory Techniques: Volume Transfers with Serological Pipettes and Micropipettors

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Published on: May 31, 2012

Surreptitious pipetting errors on a vendor-programmed liquid handler.

Kelly Britt-Rodriquez¹, Jamie Daniel¹, Joshua Hayden²

¹Medical Technologist, CPA, Louisville, KY, USA.

Journal of Mass Spectrometry and Advances in the Clinical Lab

|June 3, 2024

Summary

Automated liquid handlers (LHs) can still mis-pipette samples, leading to critical errors. Rigorous laboratory validation is essential to catch these errors and prevent patient harm.

Keywords:

Liquid handlers Mass spectrometry

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Area of Science:

Laboratory Automation
Clinical Diagnostics
Biotechnology

Background:

Liquid handlers (LHs) are widely adopted in clinical and academic labs for sample preparation.
These automated systems aim to reduce errors, particularly mis-pipetting, compared to manual methods.

Observation:

This report details two cases of incorrect pipetting by vendor-programmed LHs.
The actual pipetted volumes did not match the generated worklists in both instances.

Findings:

These discrepancies represent significant near misses with potential for serious patient harm.
The errors were not detected during the laboratories' initial validation of the LH systems.

Implications:

Laboratories must be vigilant about the potential for mis-pipetting errors with LHs.
LH vendors should improve software to ensure worklists accurately reflect pipetted actions.
End-users need to implement comprehensive validation protocols covering diverse real-world scenarios.