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Multifactorial analysis of willingness to undergo subcutaneous allergen immunotherapy in pediatric patients
Bo Ding1, Jie Zhong2, Chun Jiang3
1Bo Ding, Department of Pediatrics, Renji Hospital Affiliated to, Shanghai JiaoTong University School of Medicine, 2000 Jiangyue Road, Shanghai 201112, P.R. China.
Insights
Pediatric patients
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Public Health
Background:
- Allergic respiratory diseases significantly impact children's quality of life.
- Allergen immunotherapy (AIT) offers a disease-modifying treatment option.
- Understanding factors influencing AIT acceptance is crucial for improving treatment adherence.
Purpose of the Study:
- To identify key factors influencing the acceptance of allergen immunotherapy (AIT) among pediatric patients and their families.
- To explore the relationship between disease characteristics, parental knowledge, and physician recommendations on AIT willingness.
- To provide insights for enhancing AIT adoption in pediatric allergy care.
Main Methods:
- A survey of 406 pediatric patients (ages not specified) with allergic respiratory diseases was conducted.
- An online questionnaire assessed patient demographics, allergic disease status, family history, parental knowledge, and physician recommendations.
- Statistical analyses, including univariate and multifactorial logistic regression, were used to identify significant influencing factors.
Main Results:
- Factors significantly associated with AIT willingness included allergic rhinitis (AR) severity, asthma (AS) severity, parental knowledge of allergic diseases, and physician recommendation (p < 0.05).
- Multifactorial analysis confirmed that AR/AS severity, parental knowledge, and doctor's recommendation were independent predictors of AIT acceptance.
- Other factors like drug allergy, severe reaction history, mother's education, and distance to hospital showed statistical differences but were not independent predictors in the final model.
Conclusions:
- The severity of allergic rhinitis and asthma, coupled with parental understanding and physician endorsement, are critical determinants of pediatric AIT acceptance.
- Targeted patient education and strong physician recommendations can significantly improve willingness to undergo AIT for pediatric allergic respiratory diseases.
- Addressing parental knowledge gaps and clearly communicating the benefits of AIT are essential for successful treatment implementation in children.
Objective:
To explore factors influencing the acceptance of allergen immunotherapy (AIT) for the treatment of allergic respiratory diseases by pediatric patients and their families.
Methods:
A total of 406 children (210 males and 196 females) attending the pediatric outpatient clinics and wards of the Renji Hospital, Shanghai Jiao Tong University School of Medicine from June 2020 to April 2022. Those who met the criteria for the AIT treatment, were included in the survey. An online 20-item questionnaire was developed. Data on patient's general characteristics, allergic disease status, family history of allergies, general family information, parental knowledge of allergic diseases, and whether the AIT treatment was recommended by a physician, were collected. The patients were divided into two groups according to their willingness to receive AIT: a reluctant or neutral group (n = 182), and a willing group (n = 224). A univariate analysis of the willingness to undergo AIT was done to detect parameters that significantly differed between the groups, and the identified factors were used as independent variables in the multifactorial logistic regression analysis.
Results:
The severity of allergic disease, presence of drug allergy, occurrence of severe allergic reactions, mother's education, distance from home to the hospital, parental knowledge of allergic diseases, and whether the doctor recommended AIT were all statistically different between the groups (p < 0.05). Multifactorial logistic regression analysis showed that the degree of allergic rhinitis (AR), or asthma (AS), parental knowledge of allergic diseases, and doctor's recommendation of AIT were the factors that influenced the willingness of pediatric patients to receive AIT.
Conclusions:
The severity of AR and AS, parental knowledge of allergic diseases, and doctor's recommendation influenced the willingness of pediatric patients to receive AIT.
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