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Updated: Jun 24, 2025

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

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Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease - A system

Stephen T Vernon1,2,3, Stuart Brentnall4, Danielle J Currie4

  • 1Cardiovascular Discovery Group, Kolling Institute of Medical Research, University of Sydney, Australia.

American Journal of Preventive Cardiology
|June 3, 2024
PubMed

Insights

Integrating Polygenic Risk Scores (PRS) into Australia's cardiovascular disease prevention programs can significantly reduce deaths and improve health outcomes. Wider adoption of PRS offers greater cost-effectiveness and societal benefits for cardiovascular health.

Area of Science:

  • Cardiovascular disease prevention
  • Genomics in healthcare
  • Health economics

Background:

  • Traditional risk scores inadequately identify individuals at risk of acute cardiovascular events.
  • There is a need to enhance primary prevention strategies for cardiovascular disease (CVD).

Purpose of the Study:

  • To model the impact and cost-effectiveness of integrating Polygenic Risk Scores (PRS) into Australia's CVD primary prevention program.
  • To assess the economic benefits of using PRS alongside traditional risk scores.

Main Methods:

  • Utilized system dynamics models to simulate acute and chronic CVD care in Australia over a 10-year horizon.
  • Assessed the cost-effectiveness of incorporating a Coronary Artery Disease PRS (CAD-PRS) in primary prevention.
  • Modeled pragmatic integration of CAD-PRS for individuals at low/moderate risk via Heart Health Checks.

Main Results:

  • Pragmatic CAD-PRS integration could prevent 2,052 deaths and gain 24,085 QALYs at $19,945/QALY, yielding a $724 million net benefit.
  • Widespread use (all Australians >35) could prevent 12,374 deaths and 60,284 acute coronary events, gaining 183,682 QALYs at $18,531/QALY, with a $5.78 billion net benefit.

Conclusions:

  • Incorporating CAD-PRS into Australian primary prevention offers significant health and economic advantages.
  • Increased uptake of CAD-PRS in primary prevention leads to greater impact and cost-effectiveness.
  • CAD-PRS represents a valuable tool for enhancing cardiovascular disease primary prevention strategies.
Abstract

Keywords:
Cardiovascular diseaseCoronary artery diseaseHealth economicsPolygenic risk score

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