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Association of Alzheimer's Disease With Peripheral Vestibular Disorder: A Case-Control Study
Shih-Han Hung1,2,3, Sudha Xirasagar4, Yen-Fu Cheng5,6,7,8
1Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
The Laryngoscope
|June 3, 2024
Summary
Individuals with Alzheimer's disease were twice as likely to have a prior peripheral vestibular disorder diagnosis. This suggests potential shared pathways between Alzheimer's disease and vestibular dysfunction.
Area of Science:
- Neurology
- Geriatrics
- Otolaryngology
Background:
- Vestibular disorders affect cognitive functions like memory and spatial orientation, overlapping with Alzheimer's disease symptoms.
- Understanding potential links between these conditions is crucial for early diagnosis and management in the elderly.
Purpose of the Study:
- To investigate the association between Alzheimer's disease (AD) and prior diagnoses of peripheral vestibular disorders (PVD).
- To analyze this association within the elderly Taiwanese population.
Main Methods:
- A case-control study utilized data from Taiwan's Longitudinal Health Insurance Database 2010.
- 3138 Alzheimer's disease cases were propensity-matched with 9414 controls.
- Multivariable logistic regression analyzed the association, adjusting for sociodemographic factors and comorbidities.
Main Results:
- A significantly higher prevalence of prior PVD was observed in AD patients (20.6%) compared to controls (11.4%).
- AD patients were twice as likely to have a prior PVD diagnosis (aOR = 2.040, 95% CI: 1.829-2.274).
Conclusions:
- Findings indicate a significant association between Alzheimer's disease and prior peripheral vestibular disorders.
- This suggests potential shared or related pathophysiological mechanisms underlying both conditions.
