[A race against time: POEMS syndrome]

Area of Science:

• Neurology
• Hematology
• Oncology

Background:

• POEMS syndrome is a complex multisystem disorder.
• Early diagnosis is critical to prevent severe multiorgan damage.
• Despite therapeutic advancements, diagnosis remains challenging for physicians.

Observation:

• Presents two cases of POEMS syndrome with prolonged undiagnosed polyneuropathy.
• Illustrates the significant consequences of delayed POEMS syndrome diagnosis.
• Demonstrates that therapeutic options exist even with multiorgan impairment.

Findings:

• Late diagnosis of POEMS syndrome can lead to severe, irreversible multiorgan damage.
• Despite advanced disease, treatment can still improve patient outcomes.
• Highlights the importance of considering POEMS syndrome in undiagnosed polyneuropathies.

Implications:

• Emphasizes the need for increased physician awareness and prompt diagnosis of POEMS syndrome.
• Underscores the potential for improved patient prognosis with timely intervention.
• Suggests a cautious and prudent approach to polyneuropathy treatment initiation.