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Updated: Jun 24, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease

Huan Zhou1, Lingqiu Dong1, Xiang Liu2

  • 1Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China.

International Urology and Nephrology
|June 3, 2024
PubMed

Insights

Heart rate non-dipping is common in patients with chronic kidney disease and hypertension. This pattern is linked to worse kidney function and increased cardiac damage, highlighting the need for monitoring.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • Chronic kidney disease (CKD) and hypertension are significant health concerns.
  • Target organ damage is a major complication in these patients.
  • Heart rate (HR) patterns, specifically non-dipping, may indicate increased risk.

Purpose of the Study:

  • To investigate the association between the heart rate (HR) non-dipping pattern and target organ damage.
  • To assess the relationship in patients diagnosed with both chronic kidney disease (CKD) and hypertension.

Main Methods:

  • A cross-sectional study involving 447 patients with CKD and hypertension.
  • Utilized 24-hour ambulatory blood pressure monitoring.
  • Employed linear and logistic regression analyses to examine associations with eGFR, LVMI, and LVH.

Main Results:

  • A majority of patients (58.4%) exhibited an HR non-dipping pattern.
  • HR non-dipping was significantly associated with reduced estimated glomerular filtration rate (eGFR) and advanced CKD stages (4-5).
  • The pattern independently correlated with increased left ventricular mass index (LVMI) and left ventricular hypertrophy (LVH).

Conclusions:

  • The HR non-dipping pattern is independently linked to impaired renal function and cardiac damage in CKD patients with hypertension.
  • Detecting and managing HR non-dipping is crucial for comprehensive patient care.
  • Further attention to HR non-dipping is warranted in clinical management.
Abstract

Keywords:
Ambulatory blood pressure monitoringChronic kidney diseaseHeart rate non-dippingTarget organ damage

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