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Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative
Ricarda Jendritza1, Krunoslav Stingl2,3, Torsten Strasser1,2,4
1Pupil Research Group at the Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.
Investigative Ophthalmology & Visual Science
|June 3, 2024
Summary
Pupillary light response (PLR) is influenced by stimulus eccentricity and age, particularly in individuals over 60. This study establishes a normative database for pupillary function, validating its use as a biomarker for retinal health.
Area of Science:
- Ophthalmology
- Neuroscience
- Physiology
Background:
- The pupillary light response (PLR) serves as a crucial indicator of retinal function.
- Chromatic pupil campimetry (CPC) offers a method to evaluate localized retinal function through PLR.
- Establishing normative data is essential for interpreting PLR measurements.
Purpose of the Study:
- To investigate factors influencing the pupillary light response (PLR).
- To provide epidemiological data for a large normative collective.
- To establish a normative database for chromatic pupil campimetry (CPC) evaluation.
Main Methods:
- Measured PLR parameters in 150 healthy participants (aged 18-79) using L-cone- and rod-favoring CPC protocols.
- Utilized linear-mixed effects models to identify factors affecting PLR.
- Correlated optical coherence tomography (OCT) data with pupillary function volume.
Main Results:
- Stimulus eccentricity significantly impacted relative maximal constriction amplitude (relMCA) and latency for both L-cone and rod stimulation (P < 0.0001).
- Age significantly affected latency under rod-specific stimulation, showing prolongation in individuals ≥60 years.
- Baseline pupil diameter decreased significantly with age under both photopic and scotopic conditions (P < 0.0001).
Conclusions:
- Stimulus eccentricity is the primary factor influencing PLR parameters.
- Age-related latency prolongation under scotopic conditions is confirmed.
- A representative normative database for PLR parameters was established, validating CPC's utility as a biomarker for retinal function.
