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Related Concept Videos

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Related Experiment Video

Updated: Jun 24, 2025

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[NETosis in lupus nephritis].

T M Reshetnyak1,2, K S Nurbaeva1,2, I V Ptashnik3

  • 1Nasonova Research Institute of Rheumatology.

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|June 3, 2024
PubMed
Summary

Elevated levels of myeloperoxidase-DNA (MPO-DNA) complex were found in 39% of patients with systemic lupus erythematosus (SLE). This MPO-DNA complex is associated with lupus nephritis (LN) activity and renal damage in SLE patients.

Keywords:
MPO-DNA complexNETosisNETslupus nephritissystemic lupus erythematosus

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Area of Science:

  • Immunology
  • Rheumatology
  • Nephrology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with potential organ damage.
  • Lupus nephritis (LN) is a severe manifestation of SLE, impacting kidney function.
  • Myeloperoxidase (MPO) is an enzyme released during neutrophil activation, and MPO-DNA complexes are markers of NETosis.

Purpose of the Study:

  • To evaluate MPO-DNA complex levels in SLE patients.
  • To assess the association between MPO-DNA complex levels and the presence and activity of LN.

Main Methods:

  • Serum MPO-DNA complex levels were measured using ELISA in 77 SLE patients and 20 healthy controls.
  • SLE patients included those with and without anti-phospholipid syndrome (APS).
  • Associations with LN history, active LN, urinalysis findings, and SLEDAI-R were analyzed.

Main Results:

  • SLE patients exhibited significantly higher MPO-DNA complex levels than controls (p=0.001).
  • Elevated MPO-DNA complex levels were associated with a history of LN (p=0.009) and active LN (p=0.034).
  • MPO-DNA complex levels correlated with proteinuria, hematuria, casts, leukocyturia, and SLEDAI-R in active LN.

Conclusions:

  • 39% of SLE patients had elevated MPO-DNA complex levels.
  • Elevated MPO-DNA complex is linked to a higher prevalence and activity of LN.
  • MPO-DNA complex may serve as a potential biomarker for renal damage activity in SLE.