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Updated: Jun 24, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342

Christopher Dirks1, Henri Colyn Bwanika1, Ann-Sofie Jemth1

  • 1SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Nucleosides, Nucleotides & Nucleic Acids
|June 3, 2024
PubMed

Keywords:
SAMHD1TH6342dNTP hydrolasemode-of-inhibitionsmall molecule inhibitor

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