Circulating tumor cells are a good predictor of tumor recurrence in clinical patients with gastric cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Circulating tumor cells (CTCs) are a promising prognostic marker in gastric cancer. Higher CTC counts before surgery predict shorter disease-free survival, indicating their potential as a liquid biopsy tool.
Area Of Science
- Oncology
- Molecular Diagnostics
- Cancer Research
Background
- Circulating tumor cells (CTCs) show potential as a liquid biopsy for cancer research and clinical applications.
- The prognostic value of CTCs in gastric cancer remains unclear.
- Early detection and monitoring of cancer progression are crucial for patient outcomes.
Purpose Of The Study
- To investigate the potential of circulating tumor cells (CTCs) as prognostic predictors in patients with gastric cancer.
- To evaluate the correlation between CTC counts and clinical endpoints like disease-free survival (DFS) and overall survival (OS).
- To determine if CTC detection can serve as an independent prognostic factor in gastric cancer.
Main Methods
- 120 gastric cancer patients were enrolled before radical surgical resection.
- CTC detection was performed using the NEimFISH method, defining CTC-positive (≥2 CTCs/7.5 mL) and CTC-negative (<2 CTCs/7.5 mL) groups.
- Disease-free survival (DFS) and overall survival (OS) were evaluated using univariate and multivariate Cox proportional hazard models.
Main Results
- 64.17% of patients were CTC-positive before surgery; higher rates were observed in advanced stages.
- CTC counts increased with disease progression (median 2 vs. 5 per 7.5 mL at recurrence).
- CTC-positive patients had significantly shorter DFS (44.52 months) compared to CTC-negative patients (74.99 months) (HR=4.550, P=0.018).
- Age, D-dimer, and lymph node metastasis were correlated with CTC counts.
- While OS was shorter in CTC-positive patients, the difference was not statistically significant (P=0.083).
Conclusions
- Circulating tumor cells (CTCs) are an independent predictor of shorter disease-free survival in gastric cancer.
- The number of CTCs correlates with disease progression.
- Further studies are needed to clarify the relationship between CTCs and overall survival in gastric cancer.
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