Related Experiment Video
Updated: Jun 24, 2025
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
3.2K
Lay advisor interventions for hypertension outcomes: A Systematic Review, Meta-analysis and a RE-AIM evaluation
Sonal J Patil1, Vishwa Bhayani2, Yilin Yoshida3
1Center for Health Equity, Engagement, Education, and Research (CHEEER), Department of Family Medicine, The MetroHealth Campus of Case Western Reserve University, Cleveland, OH, United States.
Frontiers in Medicine
|June 4, 2024
Summary
Lay advisor interventions effectively lower blood pressure (BP) in adults with hypertension, especially high-intensity programs. However, factors for successful, sustained implementation in health systems require further investigation.
Area of Science:
- Public Health
- Cardiovascular Health
- Health Services Research
Background:
- Hypertension management remains a global health challenge, necessitating innovative and accessible interventions.
- Lay advisor interventions show promise, but their effectiveness and implementation factors within healthcare systems need clarification.
Approach:
- A systematic review and meta-analysis of studies on lay advisor interventions for hypertension was conducted.
- Searched multiple databases (Ovid MEDLINE, CINAHL, PsycINFO) from 1981-2023, including 41 articles (22 RCTs).
- Analyzed intervention benefits and implementation factors using the RE-AIM framework.
Key Points:
- Lay advisor interventions significantly reduced systolic BP (-3.72 mm Hg) and diastolic BP (-1.7 mm Hg) compared to controls.
- High-intensity lay advisor interventions yielded greater BP reductions than low-intensity ones.
- External validity indicators (adoption, implementation, maintenance) were rarely reported.
Conclusions:
- Lay advisor interventions are beneficial for hypertension management, with higher intensity correlating with improved outcomes.
- Further research is crucial to identify key factors for successful, scalable, and sustainable implementation of these interventions in diverse healthcare settings.
Related Concept Videos
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
617
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
617
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
421
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
421
01:25Errors occurring during blood pressure monitoring
704
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
704
01:25Antihypertensive Drugs: Direct Renin Inhibitors
585
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
585
01:28Factors affecting Blood pressure
3.1K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.1K
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
558
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
558