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A Comprehensive Prognostic Model for Colon Adenocarcinoma Depending on Nuclear-Mitochondrial-Related Genes
Lingling Lv1, Yuqing Huang1, Qiong Li1
1Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Technology in Cancer Research & Treatment
|June 4, 2024
Summary
A new prognostic model for colon adenocarcinoma (COAD) identifies nine nuclear mitochondrial-related genes (NMRGs) to predict patient outcomes and immune microenvironment characteristics, aiding in treatment strategies.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Colon adenocarcinoma (COAD) incidence is rising, with mitochondria playing a key role in tumorigenesis, yet their genetic link to COAD is unclear.
- Mitochondria are crucial for cellular energy, reactive oxygen species production, and apoptosis, influencing cancer development and progression.
Purpose of the Study:
- To investigate the relationship between mitochondrial genes and colon adenocarcinoma (COAD).
- To construct a prognostic model and nomogram for COAD based on nuclear mitochondrial-related genes (NMRGs).
- To analyze NMRG mutations, the tumor immune microenvironment, and validate findings in a liver metastasis model.
Main Methods:
- Utilized COAD data from the UCSC Xena database (512 samples).
- Developed a risk score (RS) model and prognostic nomogram using bioinformatics.
- Constructed a colorectal cancer liver metastasis model and performed Western blot analysis.
Main Results:
- A validated prognostic model for COAD was established, dividing patients into high and low-risk groups with significant differences in pathological stage and recurrence.
- Identified nine key NMRGs (LARS2, PARS2, ETHE1, LRPPRC, TMEM70, AARS2, ACAD9, VARS2, ATP8A2) for prognosis.
- The high-RS group exhibited inflamed immune features; LRPPRC and LARS2 expression increased in metastasis models.
Conclusions:
- A comprehensive prognostic model for COAD incorporating nine NMRGs was developed, demonstrating excellent predictive performance for age, T stage, recurrence, and overall prognosis.
- This model offers potential for improving COAD prognosis and treatment strategies by integrating nuclear-mitochondrial gene functions and immune characteristics.
