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Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study
Wenjie Dong1,2, Qiuyu Li1,2, Lei Chen1,2
1Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Renal Failure
|June 4, 2024
Summary
The gut microbiome composition, specifically the genus Dialister, may causally influence diabetic nephropathy risk. Certain bacterial taxa show protective or detrimental associations, warranting further investigation into probiotic interventions for diabetic kidney disease.
Area of Science:
- Microbiome research
- Genetics
- Nephrology
Background:
- Diabetic nephropathy (DN) risk is linked to gut microbiota (GM) composition.
- Causal relationship between GM and DN remains unclear.
Purpose of the Study:
- To investigate potential causal links between GM composition and DN risk.
- Utilize large-scale genetic association data for robust analysis.
Main Methods:
- Meta-analysis of genome-wide association studies (GWAS) from the MiBioGen consortium for GM data.
- Utilized IEU database for DN data.
- Employed inverse-variance weighting (IVW) for causal inference.
Main Results:
- Genus *Dialister* showed a protective effect against DN (OR=0.51, p=0.00118).
- Protective associations also observed for *Gammaproteobacteria*, *Lentisphaeria*, *Victivallales*, and *Proteobacteria*.
- Increased DN risk associated with *LachnospiraceaeUCG008*, *Bacteroidales*, and *Terrisporobacter*.
Conclusions:
- Established a potential causal protective relationship between genus *Dialister* and diabetic nephropathy.
- Identified other bacterial taxa associated with DN risk.
- Further research needed to confirm probiotic effects and mechanisms of *Dialister* in DN.
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