Related Experiment Video
Updated: May 2, 2026
08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
13.8K
Candida albicans and Candida glabrata: global priority pathogens
Myrto Katsipoulaki1, Mark H T Stappers2, Dhara Malavia-Jones2
1Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, Jena, Germany.
Microbiology and Molecular Biology Reviews : MMBR
|June 4, 2024
Summary
The World Health Organization highlights Candida species due to rising infections. This review details Candida albicans and Candida glabrata, two key fungal pathogens, examining their biology, interactions, and resistance.
Area of Science:
- Mycology
- Infectious Diseases
- Immunology
Background:
- Increasing incidence of Candida-mediated infections globally.
- Candida species identified as priority pathogens by the World Health Organization.
- Rising numbers of immunocompromised individuals contribute to infection rates.
Purpose of the Study:
- To synthesize current knowledge on Candida albicans and Candida glabrata.
- To compare and contrast the biology, pathogenicity, and host interactions of these two species.
- To review advances in understanding antifungal resistance in these fungi.
Main Methods:
- Literature review and synthesis of existing research.
- Comparative analysis of biological and epidemiological data.
- Examination of immune system interactions and virulence factors.
Main Results:
- Candida albicans is a critical priority pathogen and the leading cause of candidemia.
- Candida glabrata is a high-priority pathogen, increasingly implicated in candidemia.
- Both species exhibit distinct strategies for adhesion, invasion, immune evasion, and host damage.
Conclusions:
- Candida albicans and Candida glabrata, despite phylogenetic differences, are significant human pathogens.
- Understanding their unique biological and pathogenic mechanisms is crucial for effective treatment.
- Further research into antifungal resistance is essential for managing these infections.
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