Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Validation of a Crotonylation-Related Prognostic Risk Model for Cholangiocarcinoma Based on Integrative Transcriptome Analysis.

Digestive diseases and sciences·2026
Same author

Privacy-Preserving Virtual Contrast-enhanced MRI for Nasopharyngeal Carcinoma: A Multi-center Study.

International journal of radiation oncology, biology, physics·2026
Same author

Operationalizing Digital Health Equity in Artificial Intelligence-Enabled Patient Decision Aids for Older Adults: Mixed Methods Study.

Journal of medical Internet research·2026
Same author

Deep learning-enabled self-powered bimodal flexible sensor for intelligent access control.

Nanotechnology·2026
Same author

Tianhuang Formula and its active ingredient GsRg1 ameliorate central insulin resistance and oxidative stress by enhancing hypothalamic autophagy.

Journal of ethnopharmacology·2026
Same author

Optimization of a Wedge Shaped T-Type Magnetic Flux Concentrator for High-Sensitivity TMR Sensors.

Micromachines·2026

Related Experiment Video

Updated: Jun 24, 2025

Magnetic Tweezers for the Measurement of Twist and Torque
11:41

Magnetic Tweezers for the Measurement of Twist and Torque

Published on: May 19, 2014

23.2K

Development and Comprehensive Evaluation of TMR Sensor-Based Magnetrodes.

Jiahui Luo1,2, Zhaojie Xu1,2, Zhenhu Jin1,2

  • 1State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China.

ACS Applied Materials & Interfaces
|June 4, 2024
PubMed
Summary

New tunnel magnetoresistance (TMR) magnetrodes offer high sensitivity for detecting weak magnetic signals in biological systems. These TMR sensors enable precise local magnetic field detection, crucial for neuroscience research.

Keywords:
biosensingmagnetoresistive sensorsmagnetrodeneural probetunnel magnetoresistance (TMR)

More Related Videos

Quantifying the Relative Thickness of Conductive Ferromagnetic Materials Using Detector Coil-Based Pulsed Eddy Current Sensors
06:17

Quantifying the Relative Thickness of Conductive Ferromagnetic Materials Using Detector Coil-Based Pulsed Eddy Current Sensors

Published on: January 16, 2020

5.7K
Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation
08:24

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Published on: August 16, 2021

5.9K

Related Experiment Videos

Last Updated: Jun 24, 2025

Magnetic Tweezers for the Measurement of Twist and Torque
11:41

Magnetic Tweezers for the Measurement of Twist and Torque

Published on: May 19, 2014

23.2K
Quantifying the Relative Thickness of Conductive Ferromagnetic Materials Using Detector Coil-Based Pulsed Eddy Current Sensors
06:17

Quantifying the Relative Thickness of Conductive Ferromagnetic Materials Using Detector Coil-Based Pulsed Eddy Current Sensors

Published on: January 16, 2020

5.7K
Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation
08:24

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Published on: August 16, 2021

5.9K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Magnetoresistance (MR) sensors are valuable for detecting weak magnetic signals in biological systems due to their sensitivity and compact size.
  • Existing research often focuses on giant magnetoresistance (GMR) sensors, but tunnel magnetoresistance (TMR) sensors offer superior sensitivity.
  • Magnetrodes, integrating MR sensors with needle-shaped substrates, are designed for in-brain local magnetic field detection.

Purpose of the Study:

  • To introduce and characterize novel TMR-based magnetrodes for enhanced local magnetic field detection in biological systems.
  • To investigate the impact of varying free layer aspect ratios, junction designs, and arrangements on TMR sensor detectivity.
  • To enable the detection of neuronal magnetic signals with high spatial resolution and sensitivity.

Main Methods:

  • Fabrication of TMR-based magnetrodes with TMR sensors at the tip and midsection.
  • Design and optimization of magnetrodes with varied free layer aspect ratios and junction configurations.
  • Characterization using a custom-built magnetotransport and noise measurement system.

Main Results:

  • The developed TMR-based magnetrode achieved a limit of detection (LOD) of 300pT/ at 1 kHz.
  • Optimized designs with varied aspect ratios and junction configurations enhanced sensor detectivity.
  • The sensor's sensitivity allows for the potential distinction of neuronal spikes with minimal signal averaging.

Conclusions:

  • TMR-based magnetrodes represent a significant advancement in sensitive local magnetic field detection for biological applications.
  • These devices facilitate the study of weak magnetic signals, such as those from neuronal activity.
  • The high sensitivity and spatial resolution of TMR magnetrodes open new avenues for neuroscientific investigation.