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Published on: January 27, 2019
Potential biomarkers used for risk estimation of pediatric sepsis-associated organ dysfunction and immune
Theerapon Jariyasakoolroj1, Siriporn C Chattipakorn2,3,4, Nipon Chattipakorn5,6,7
1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Insights
Pediatric sepsis, a global health threat, requires better understanding of organ dysfunction. Biomarkers offer promise for early detection and personalized treatment strategies in children with sepsis.
Area of Science:
- Pediatric critical care medicine
- Infectious diseases
- Biomarker research
Background:
- Pediatric sepsis is a leading cause of mortality in children worldwide.
- Refractory septic shock and multiple organ dysfunction syndrome (MODS) are primary drivers of death.
- Current understanding of sepsis-associated organ dysfunction mechanisms in children remains incomplete.
Purpose of the Study:
- To review clinically utilized biomarkers linked to immune dysregulation and organ dysfunction in pediatric sepsis.
- To explore the potential of these biomarkers in developing precision medicine approaches for pediatric sepsis management.
- To highlight the need for further research into phase-specific biomarkers for improved patient outcomes.
Main Methods:
- Literature review of clinically used biomarkers in pediatric sepsis.
- Focus on biomarkers associated with immune response and organ damage.
- Analysis of biomarker utility in risk stratification and treatment guidance.
Main Results:
- Biomarkers can aid in screening, diagnosis, and prognostication of pediatric sepsis.
- Immune dysregulation and organ dysfunction biomarkers are crucial for identifying high-risk patients.
- Existing biomarkers provide insights into sepsis progression and potential therapeutic targets.
Conclusions:
- Biomarkers are vital tools for managing pediatric sepsis and its complications.
- Precision medicine strategies in pediatric sepsis can be advanced through biomarker research.
- Further well-designed studies are essential to identify specific biomarkers for improved clinical management and outcomes.
Abstract:
Pediatric sepsis is a serious issue globally and is a significant cause of illness and death among infants and children. Refractory septic shock and multiple organ dysfunction syndrome are the primary causes of mortality in children with sepsis. However, there is incomplete understanding of mechanistic insight of sepsis associated organ dysfunction. Biomarkers present during the body's response to infection-related inflammation can be used for screening, diagnosis, risk stratification/prognostication, and/or guidance in treatment decision-making. Research on biomarkers in children with sepsis can provide information about the risk of poor outcomes and sepsis-related organ dysfunction. This review focuses on clinically used biomarkers associated with immune dysregulation and organ dysfunction in pediatric sepsis, which could be useful for developing precision medicine strategies in pediatric sepsis management in the future. IMPACT: Sepsis is a complex syndrome with diverse clinical presentations, where organ dysfunction is a key factor in morbidity and mortality. Early detection of organ complications is vital in sepsis management, and potential biomarkers offer promise for precision medicine in pediatric cases. Well-designed studies are needed to identify phase-specific biomarkers and improve outcomes through more precise management.
