Role of secreted frizzled-related protein 4 in prediabetes and type 2 diabetes: a cross sectional study
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View abstract on PubMed
Summary
This summary is machine-generated.Secreted frizzled-related protein 4 (SFRP4) levels are elevated in prediabetes and type 2 diabetes (T2D). Higher SFRP4 may indicate increased risk for developing T2D, warranting further research.
Area Of Science
- Endocrinology
- Metabolic Diseases
- Biomarker Discovery
Background
- Type 2 diabetes (T2D) is a growing epidemic with significant complications.
- Delayed diagnosis and treatment contribute to high mortality rates.
- Secreted frizzled-related protein 4 (SFRP4) is a potential early biomarker for T2D, linked to inflammation and impaired glucose metabolism.
Purpose Of The Study
- To investigate the role of SFRP4 in prediabetes and T2D.
- To evaluate SFRP4 as an early biomarker in a Mexican population.
Main Methods
- Cross-sectional study with 80 T2D patients, 50 prediabetes patients, and 50 healthy controls.
- Measured fasting SFRP4 and insulin via ELISA.
- Quantified serum inflammatory markers (IL-10, IL-6, IL-1β, IL-8) using flow cytometry.
- Performed genotyping using TaqMan® probes.
Main Results
- SFRP4 levels were significantly higher in prediabetes and T2D patients compared to controls.
- Prediabetes and T2D groups showed increased pro-inflammatory cytokines (IL-6, IL-1β, IL-8) and decreased anti-inflammatory IL-10.
- SFRP4 positively correlated with HbA1c and HOMA-IR, and inflammatory markers, even after adjusting for BMI and age.
- Genetic variant rs4720265 correlated with low HDL in T2D patients.
Conclusions
- SFRP4 levels correlate with prediabetes, suggesting potential as an early predictive biomarker for diabetes risk.
- Further longitudinal studies are needed to confirm SFRP4's predictive value.
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