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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Updated: Jun 24, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Osteosarcoma in a ceRNET perspective.

Nicola Mosca1, Nicola Alessio2, Alessandra Di Paola3

  • 1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy.

Journal of Biomedical Science
|June 4, 2024
PubMed
Summary
This summary is machine-generated.

Osteosarcoma (OS) progression is driven by disrupted competing endogenous RNA networks (ceRNETs). Understanding these RNA interactions offers new therapeutic targets for this fatal bone cancer.

Keywords:
Non-coding RNAOsteosarcomaTumor microenvironmentceRNAceRNET

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Osteosarcoma (OS) is a prevalent and fatal bone tumor with significant genomic heterogeneity.
  • Current therapeutic strategies and patient management are challenged by OS complexity.
  • A unified understanding of molecular mechanisms is crucial for advancing OS treatment.

Purpose of the Study:

  • To explore the role of competing endogenous RNA networks (ceRNETs) in osteosarcoma.
  • To elucidate how ceRNET dysregulation contributes to OS initiation, progression, and therapeutic resistance.
  • To highlight the influence of the tumor microenvironment on OS-related ceRNETs.

Main Methods:

  • Review of existing studies on RNA regulatory networks in osteosarcoma.
  • Analysis of the interactions between long non-coding RNAs, circular RNAs, and mRNAs within ceRNETs.
  • Investigation of the impact of microenvironment factors on ceRNET components.

Main Results:

  • ceRNETs, involving lncRNAs, circRNAs, and mRNAs competing for miRNAs, are implicated in OS.
  • Network component imbalance drives OS proliferation, migration, invasion, metastasis, and chemoresistance.
  • Tumor microenvironment factors like cytokines and vesicles influence OS ceRNETs.

Conclusions:

  • Dysregulated ceRNETs are key drivers of osteosarcoma pathogenesis and progression.
  • Targeting ceRNETs presents opportunities for novel RNA-based therapies and diagnostics.
  • This understanding supports the development of precision oncology strategies for OS.