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Updated: Jun 24, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.2K

The therapeutic potential of circular RNA in triple-negative breast cancer

Aiqi Xu1,2, Lewei Zhu3,2, Chengcai Yao4

  • 1Department of Breast Oncology, School of Medicine, South China University of Technology, Guangzhou 510006, Guangdong, China.

Cancer Drug Resistance (Alhambra, Calif.)
|June 5, 2024
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in triple-negative breast cancer (TNBC) development, influencing proliferation, metastasis, and the tumor microenvironment. These non-coding RNAs show promise as future therapeutic targets and biomarkers for TNBC.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype lacking standard therapeutic targets.
  • Circular RNAs (circRNAs) are non-coding RNAs with dysregulated expression in various cancers.
  • Emerging evidence links circRNAs to TNBC progression, metabolism, and immune interactions.

Purpose of the Study:

  • To review the biogenesis and function of circRNAs.
  • To summarize current research on circRNAs in TNBC.
  • To explore the potential of circRNAs as therapeutic targets and biomarkers for TNBC.

Main Methods:

  • Literature review of circRNA research in TNBC.
  • Analysis of circRNA roles in TNBC proliferation, metastasis, and metabolism.
  • Evaluation of circRNAs in the tumor immune microenvironment.

Main Results:

  • CircRNAs play critical roles in TNBC tumorigenesis and progression.
  • Specific circRNAs can promote or inhibit TNBC development.
  • CircRNAs impact TNBC cell proliferation, metastasis, and metabolic reprogramming.
  • CircRNAs influence the immune landscape within the TNBC microenvironment.

Conclusions:

  • CircRNAs are significant players in TNBC pathogenesis.
  • CircRNAs hold potential as novel biomarkers for TNBC diagnosis and prognosis.
  • CircRNAs represent promising therapeutic targets for innovative TNBC treatments.
Keywords:
Triple-negative breast cancercircular RNAnon-coding RNA

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