Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Chemosensitizing Effect Of Pentoxifylline In Sensitive And Multidrug-resistant Non-small Cell Lung Cancer Cells.

Chemosensitizing effect of pentoxifylline in sensitive and multidrug-resistant non-small cell lung cancer cells.

Beatriz S Matos1,2, Sara Peixoto da Silva1,2,3, M Helena Vasconcelos1,2,3

  • 1i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, Porto 4200-135, Portugal.

Cancer Drug Resistance (Alhambra, Calif.)
|June 5, 2024

Related Experiment Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.0K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.5K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

View abstract on PubMed

Summary
This summary is machine-generated.

Pentoxifylline combined with chemotherapy may improve non-small cell lung cancer (NSCLC) treatment by overcoming multidrug resistance (MDR). This approach enhances drug sensitivity and patient survival without significant toxicity.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Multidrug resistance (MDR) is a significant challenge in non-small cell lung cancer (NSCLC) treatment, often linked to fibrotic stroma.
  • Chitinase 3-like-1 (CHI3L1) and P-glycoprotein (P-gp) are implicated in NSCLC progression and drug resistance.

Purpose of the Study:

  • To investigate the efficacy of combining pentoxifylline, an anti-fibrotic and CHI3L1 inhibitor, with conventional chemotherapy for NSCLC.
  • To evaluate pentoxifylline's impact on MDR mechanisms and patient survival.

Main Methods:

  • Assessed pentoxifylline's effects on P-gp, CHI3L1, and downstream proteins in sensitive and MDR NSCLC cell lines.
  • Utilized The Cancer Genome Atlas (TCGA) for association studies between CHI3L1 expression and NSCLC patient survival.
  • Evaluated drug combination sensitizing effects and cytotoxicity in NSCLC and non-tumorigenic cell lines.
Keywords:
Chitinase 3-like-1combined therapiesdrug repurposingmultidrug resistance

Related Experiment Videos

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.0K
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
09:45

Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers

Published on: October 28, 2015

8.5K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

Main Results:

  • Pentoxifylline reduced CHI3L1, β-catenin, and STAT3 expression, and increased G1 phase cell cycle arrest in NSCLC cells.
  • Significant cell death increase observed in sensitive NSCLC cells; pentoxifylline sensitized both sensitive and MDR cells to chemotherapy.
  • High CHI3L1 levels correlated with lower overall survival in NSCLC patients treated with vinorelbine.

Conclusions:

  • Pentoxifylline shows potential as an adjunct therapy to chemotherapy for improving NSCLC treatment outcomes.
  • Combination therapy may overcome MDR in NSCLC, offering a new therapeutic strategy.
  • Pentoxifylline demonstrates favorable safety profile in non-tumorigenic cells.
non-small cell lung cancer
pentoxifylline