Assessment of Adverse Events Following COVID-19 Vaccination: A Cross-sectional Study in Ibadan, Nigeria
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View abstract on PubMed
Summary
This summary is machine-generated.Most recipients of the AstraZeneca/Oxford COVID-19 vaccine in Ibadan experienced mild adverse events following immunization (AEFI). Previous COVID-19 infection increased the risk of AEFI, but most reactions were self-limiting.
Area Of Science
- Immunology
- Public Health
- Epidemiology
Background
- COVID-19 vaccination is crucial for pandemic control and saving lives.
- The AstraZeneca/Oxford vaccine is a key tool in global immunization efforts.
- Understanding vaccine safety, including adverse events, is vital for public trust and vaccine uptake.
Purpose Of The Study
- To evaluate the spectrum of adverse events following immunization (AEFI) with the COVID-19 AstraZeneca/Oxford vaccine.
- To identify the frequency and types of AEFI in Ibadan, Nigeria.
- To explore factors associated with AEFI, such as previous COVID-19 infection.
Main Methods
- A cross-sectional study involving 369 adults vaccinated with AstraZeneca/Oxford COVID-19 vaccine in Ibadan, Nigeria.
- Data collected via structured questionnaires on adverse events following immunization.
- Analysis of AEFI frequency, types, timing, and associated risk factors.
Main Results
- 90% of participants reported at least one AEFI.
- Most frequent AEFI included headache (21.1%), fatigue (17.4%), and injection site pain (9.3%).
- 96.4% of AEFI occurred within 48 hours; severe AEFI occurred in 1.2%. Previous COVID-19 infection increased AEFI odds (OR 7.0).
Conclusions
- The study found a high frequency of AEFI with the AstraZeneca/Oxford vaccine in Ibadan.
- The majority of reported AEFI were mild and self-limiting.
- Previous COVID-19 infection is a significant risk factor for experiencing AEFI.
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