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Resident Microbiome of Kidney Tumors
Olga Kovaleva1, Polina Podlesnaya1, Alexei Gratchev1
1N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Oncology Reviews
|June 5, 2024
Summary
The kidney microbiome plays a role in cancer development. Alterations in kidney and gut bacteria impact kidney tumor characteristics and treatment effectiveness, highlighting the need for further research.
Area of Science:
- Microbiology
- Oncology
- Genitourinary Medicine
Background:
- The human microbiome, particularly bacteria, is increasingly recognized for its role in carcinogenesis, with infectious agents linked to approximately 15% of malignant tumors.
- The kidney microbiome's composition and its alterations in disease states, including kidney cancer, are areas of active investigation.
- Gut microbiome modulation by factors like antibiotics can influence the efficacy of treatments for malignant kidney tumors.
Purpose of the Study:
- To review the current understanding of the resident kidney microbiome.
- To explore the composition and alterations of the kidney microbiome in various kidney diseases, with a focus on malignant tumors.
- To discuss the clinical relevance of kidney microbiome research in diagnosis, prognosis, and therapeutic outcomes.
Main Methods:
- Literature review of recent studies on kidney microbiome composition and its association with kidney tumors.
- Analysis of research investigating bacterial infiltration and distinct microbial signatures in normal versus tumor kidney tissues.
- Examination of studies correlating gut microbiome status and antibiotic use with therapeutic responses in kidney cancer patients.
Main Results:
- Distinct bacterial communities are found in normal kidney tissue compared to kidney tumor tissue.
- Specific microbial taxa are associated with different histological types of kidney tumors.
- Alpha diversity indices indicate variations in bacterial content between tumor and normal kidney tissues, suggesting diagnostic and prognostic potential.
- Gut microbiome alterations, influenced by antibiotics, are linked to survival outcomes in patients undergoing targeted therapy and immunotherapy for kidney cancer.
Conclusions:
- The resident kidney microbiome exhibits distinct characteristics in the presence of tumors, offering potential biomarkers.
- Modulation of the gut microbiome can significantly impact the effectiveness of treatments for malignant kidney tumors.
- Further in-depth investigation of the kidney microbiome is crucial for understanding kidney tumor development and improving patient outcomes.
