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Effects of cell-free DNA on kidney disease and intervention strategies

Mingying Zhang1, Yubin Cai1, Xiaoze Zhong1

  • 1Department of Nephrology, Jieyang People's Hospital, Jieyang, China.

Frontiers in Pharmacology
|June 5, 2024
PubMed

Insights

Chronic kidney disease poses a global health challenge. This review explores cell-free DNA (cfDNA) in kidney disease and removal strategies for novel therapeutic targets.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Kidney disease is a significant global health issue, impacting patients with end-stage renal disease who require dialysis or transplantation.
  • Developing early-stage interventions for chronic kidney disease is crucial to alleviate patient and societal burdens.

Purpose of the Study:

  • To review the current understanding of cell-free DNA (cfDNA) roles in kidney disease.
  • To explore strategies for the targeted removal of cfDNA as a potential therapeutic approach for kidney disease.

Main Methods:

  • Literature review of studies on cfDNA in kidney disease.
  • Analysis of existing and proposed cfDNA removal techniques.

Main Results:

  • Cell-free DNA (cfDNA) is increasingly recognized for its involvement in kidney disease pathogenesis.
  • Various strategies for cfDNA targeted removal are being investigated.

Conclusions:

  • Cell-free DNA (cfDNA) presents a promising area for novel therapeutic targets in kidney disease.
  • Targeted cfDNA removal strategies could lead to new interventions for managing kidney disease.
Keywords:
acute kidney injurycell-free DNAchronic kidney diseasenanomaterialneutrophil extracellular traps

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