Related Experiment Video
Updated: Jun 24, 2025
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Evaluation of Delayed Contact Hypersensitivity in Patients with Rosacea
Antigoni Alevizou1, Stamatios Gregoriou1, Antonios Tsimpidakis1
11st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Medical School, "Andreas Syggros" Hospital for Cutaneous and Venereal Diseases, Athens, Greece.
Introduction:
Rosacea is a common chronic inflammatory dermatosis characterized by erythema, telangiectasia, papules, and pustules on the central face. The frequency of contact sensitization complicating rosacea and its therapy is unknown, with only few studies published in the literature. In the present study, we aimed to evaluate contact sensitivity in patients with rosacea.
Methods:
A total of 50 rosacea patients and 50 age- and sex-matched healthy controls were enrolled. Both groups were patch tested with the European Baseline Series.
Results:
A positive reaction to at least one allergen of the European Baseline Series was observed in 15 (30%) of rosacea patients and 10 (20%) of the healthy controls. Although the rate of positive reaction in the rosacea group was higher than in the controls, no statistically significant difference was documented. In addition, the total number of positive reactions to allergens in the rosacea group was higher than the control group, namely, 26 versus 17.
Conclusion:
Contact hypersensitivity may coexist with rosacea. Its identification holds significant clinical relevance, influencing the long-term management and justifying the application of patch testing in rosacea patients.
