Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence Rates of Melanoma and Lung Cancer Are Generally Low in the Lynch Syndromes and Vary Across <i>path_MMR</i> Variants: A Prospective Lynch Syndrome Database Report.

Cancers·2026
Same author

A Micro-costing Study of Community-Based Primary HPV Self-Sampling and Triage Test for Cervical Cancer Screening in Rural Cambodia.

PharmacoEconomics - open·2026
Same author

KRAS and BRAF mutations modify adjuvant chemotherapy outcomes in early stage colorectal cancer.

NPJ precision oncology·2026
Same author

Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer.

JNCI cancer spectrum·2026
Same author

Immune Cell Score as a Predictor of Adjuvant Chemotherapy Effectiveness in Stage II Colorectal Cancer.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Cancer risks in the Lynch syndromes.

Journal of the National Cancer Institute·2026

Related Experiment Video

Updated: Jun 24, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K

Liquid biopsy-based early tumor and minimal residual disease detection: New perspectives for cancer predisposition

Lena Bohaumilitzky1,2, Johannes Gebert1,2, Magnus von Knebel Doeberitz1,2

  • 1Institute of Pathology University Hospital Heidelberg Heidelberg Germany.

Medizinische Genetik : Mitteilungsblatt Des Berufsverbandes Medizinische Genetik E.V
|June 5, 2024
PubMed
Summary

Genetic predisposition increases cancer risk, necessitating lifelong surveillance. Liquid biopsy shows promise for early cancer detection and monitoring in high-risk individuals, potentially improving adherence to screening protocols.

Keywords:
Liquid biopsyLynch syndromecancer predisposition syndromesclinical managementearly cancer detection

More Related Videos

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.3K
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.0K

Related Experiment Videos

Last Updated: Jun 24, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

8.6K
A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

10.3K
Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients
08:25

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

11.0K

Area of Science:

  • Oncology
  • Genetics
  • Biomarkers

Background:

  • Genetic predisposition is a significant cancer risk factor, requiring lifelong patient surveillance.
  • Current cancer screening methods are often invasive and limited to specific tumor types.
  • Hereditary cancer syndromes present unique challenges for early detection and monitoring.

Purpose of the Study:

  • To explore the potential of liquid biopsy for cancer surveillance in individuals with genetic predisposition.
  • To assess liquid biopsy's utility in detecting precancerous lesions and aiding diagnostics.
  • To evaluate liquid biopsy's role in enhancing patient adherence to surveillance protocols.

Main Methods:

  • Review of current literature on liquid biopsy applications in cancer surveillance.
  • Analysis of liquid biopsy's potential for monitoring therapy response and minimal residual disease.
  • Discussion of clinical translation pathways for liquid biopsy in high-risk populations.

Main Results:

  • Liquid biopsy offers a less invasive alternative for cancer surveillance compared to traditional methods.
  • Potential for early detection of precancerous changes and improved diagnostic capabilities.
  • Enhanced monitoring capabilities for therapy response and minimal residual disease assessment.

Conclusions:

  • Liquid biopsy holds significant promise for improving cancer surveillance in genetically predisposed individuals.
  • Clinical translation of liquid biopsy could reduce cancer risk and mortality in high-risk groups.
  • Liquid biopsy may increase patient adherence to personalized surveillance strategies.