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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Proactive Coping in Early Pregnancy and Adverse Pregnancy Outcomes
Tess E K Cersonsky1, Audra C Fain2, Adam K Lewkowitz3,4
1Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lower proactive coping in early pregnancy is linked to increased adverse perinatal outcomes. Interventions to enhance coping strategies may reduce pregnancy complications.
Area of Science:
- Reproductive Health
- Psychological Well-being
- Perinatal Medicine
Background:
- Proactive coping is linked to well-being and quality of life in chronic disease outside of pregnancy.
- Its impact on perinatal outcomes remains understudied.
- Early pregnancy is a critical period for establishing coping mechanisms.
Purpose of the Study:
- To evaluate the association between early pregnancy proactive coping and adverse perinatal outcomes.
- To investigate if proactive coping influences the risk of specific pregnancy complications.
Main Methods:
- Secondary analysis of 281 nulliparous participants recruited from a tertiary care center.
- Proactive coping assessed using the Proactive Coping Scale between 8-20 weeks gestation.
- Adverse perinatal outcomes, including composite measures, were tracked longitudinally through delivery.
Main Results:
- The median Proactive Coping Scale score was 45.0, with 47% experiencing an adverse outcome.
- Lower proactive coping scores (lowest quartile) were associated with 2.2 times higher odds of adverse perinatal outcomes.
- No significant differences were observed for individual composite components or neonatal morbidity.
Conclusions:
- Reduced proactive coping in early pregnancy correlates with a significant increase in adverse perinatal outcomes.
- Interventions aimed at improving proactive coping may offer a novel approach to reduce perinatal morbidity.
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