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Updated: Jun 24, 2025

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Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers

Zheng-Long Wu1,2, Ying Wang1, Xiao-Yuan Jia1

  • 1Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China.

World Journal of Clinical Oncology
|June 5, 2024
PubMed

Insights

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is crucial in embryonic development and cancer. This review examines ROR1's role in gastrointestinal cancer, its therapeutic potential, and challenges in treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a type I receptor tyrosine kinase.
  • ROR1 exists in soluble and membrane-bound forms, with membrane-bound ROR1 highly expressed in tumors.
  • ROR1 is evolutionarily conserved and implicated in embryonic development and cancer progression.

Purpose of the Study:

  • To review the structure, expression, and role of ROR1 in gastrointestinal cancer development.
  • To explore ROR1's involvement in cancer signaling pathways and molecular mechanisms.
  • To discuss current and future therapeutic strategies targeting ROR1 in gastrointestinal cancers.

Main Methods:

  • Literature review of studies on ROR1 structure, function, and expression.
  • Analysis of ROR1's role in cancer cell proliferation, invasiveness, and metastasis.
  • Examination of ROR1's interaction with various signaling pathways in cancer progression.

Main Results:

  • ROR1 overexpression correlates with increased tumor invasiveness and metastasis in gastrointestinal cancers.
  • ROR1 influences cell cycle regulation and stem cell characteristics.
  • ROR1 interacts with multiple signaling pathways, impacting cancer development.

Conclusions:

  • ROR1 is a significant factor in gastrointestinal cancer development and progression.
  • ROR1 serves as a potential biomarker and therapeutic target for gastrointestinal cancers.
  • Further research is needed to overcome challenges and advance ROR1-targeted therapies.
Keywords:
Antitumor strategiesGastrointestinal cancersMolecular mechanismsReceptor tyrosine kinase-like orphan receptor 1Therapeutic target

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