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Updated: Jun 24, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Genetic alterations in myeloproliferative and myelodysplastic/myeloproliferative neoplasms - a practical guide to

Constanze Kühn1, Katharina Hörst1, Hans M Kvasnicka2

  • 1MLL - Munich Leukemia Laboratory Munich Germany.

Medizinische Genetik : Mitteilungsblatt Des Berufsverbandes Medizinische Genetik E.V
|June 5, 2024
PubMed

Within the World Health Organization (WHO) classification of haematopoietic neoplasms, particularly its fifth version from 2022 (WHO-HAEM5), myeloid neoplasms are not only grouped into myeloproliferative (MPN) and myelodysplastic neoplasms (MDS). There is also a group of haematological disorders that share features of both categories termed myelodysplastic /myeloproliferative neoplasms (MDS/MPN). In this article, we aim to provide a comprehensive and practical guide to WHO-HAEM5 highlighting the genetic alterations that underlie MPN and MDS/MPN. This guide provides an overview of the overlapping commonalities among these entities, as well as their unique characteristics.

Keywords:
HAEM5WHOclassificationmyelodysplastic /myeloproliferative neoplasmsmyeloproliferative neoplasmsoverlap

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