Fluorescent probes for imaging: a focus on atherosclerosis
Jing Jia1,2, Li Li1,2, Zhifang Wu1,2
1Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China. jiajing2@sxmu.edu.cn.
Nanoscale
|June 5, 2024
Summary
This review explores advanced fluorescent probes for monitoring atherosclerosis, a dangerous inflammatory cardiovascular disease. These probes offer sensitive, real-time imaging for early detection and improved cardiovascular disease management.
Area of Science:
- Biomedical Engineering
- Molecular Imaging
- Cardiovascular Research
Background:
- Atherosclerosis is a chronic inflammatory cardiovascular disease leading to arterial stenosis and thrombosis.
- Timely monitoring of atherosclerosis is crucial for reducing acute cardiovascular events.
- Fluorescence imaging offers high sensitivity, spatiotemporal resolution, and real-time capabilities for visualizing atherosclerosis.
Purpose of the Study:
- To provide an overview of fluorescent probes for atherosclerosis detection.
- To summarize studies on various fluorescent probe applications in atherosclerosis imaging.
- To discuss biological targets, progress, and limitations of current probes.
Main Methods:
- Review of scientific literature on fluorescent probes for atherosclerosis.
- Analysis of single-mode and multimodal fluorescent probe designs.
- Evaluation of probe applications in different stages of atherosclerosis.
Main Results:
- Development of diverse fluorescent probes, from single-mode to multimodal, for atherosclerosis.
- Demonstrated utility of probes in early and advanced stages of atherosclerosis detection.
- Identification of effective biological targets for probe development.
Conclusions:
- Fluorescent probes are vital tools for sensitive and real-time atherosclerosis imaging.
- Further development is needed for more accurate and efficient probes.
- Future research should focus on next-generation probes for improved atherosclerosis management.
