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  11. Super-enhancer-driven Ameboidal-type Cell Migration-related Mmp14 Expression In Tongue Squamous Cell Carcinoma Switched By Batf And Atf3

Super-enhancer-driven ameboidal-type cell migration-related MMP14 expression in tongue squamous cell carcinoma switched by BATF and ATF3

Zhimin Shi1, Rui Wang2, Jie Huang2

  • 1Department of Immunology, the School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.

The Journal of Pharmacy and Pharmacology
|June 5, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Super-enhancers (SEs) and transcription factors like BATF and ATF3 regulate MMP14 expression, a key driver of tongue squamous cell carcinoma (TSCC) metastasis. These findings offer potential therapeutic targets for TSCC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Tongue squamous cell carcinoma (TSCC) is characterized by aggressive metastasis, leading to poor prognosis and functional loss.
  • Identifying key regulators of TSCC metastasis is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the transcriptional and epigenetic characteristics associated with cancer cell migration in TSCC.
  • To identify pivotal switches governing tumor metastasis in TSCC.

Main Methods:

  • Profiling of transcriptional and epigenetic features related to cancer cell migration in TSCC.
  • Identification and analysis of super-enhancers (SEs) and their associated genes.
  • Functional studies to elucidate molecular mechanisms of metastasis regulation.
Keywords:
super-enhancertongue squamous cell carcinomatumor metastasis

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Main Results:

  • Enrichment of ameboidal-type cell migration genes with significant transcriptional and epigenetic activity in TSCC.
  • Identification of differentially expressed SE-related genes between TSCC tumors and normal tissues.
  • Discovery that transcription factors BATF and ATF3 regulate MMP14 expression via SE interaction, impacting TSCC survival.

Conclusions:

  • Super-enhancers and associated motifs transcriptionally regulate MMP14, a key factor in TSCC metastasis.
  • MMP14 and its regulatory network represent potential therapeutic targets for tongue squamous cell carcinoma.