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Effect of omega-3 fatty acid supplementation on markers of inflammation and endothelial function in patients with
Mohammed Ibrahim Mohialdeen Gubari1
1Department of Clinical Science, College of Medicine, University of Sulaimani, Kurdistan Region- Iraq. Mohammed.jubari@gmail.com.
Summary
Omega-3 fatty acid supplementation significantly reduces inflammation markers like IL-6, hs-CRP, and TNF-α in patients with chronic heart disease (CHD). It also improves endothelial function, highlighting its therapeutic potential for CHD management.
Area of Science:
- Cardiovascular Medicine
- Nutritional Science
- Biochemistry
Background:
- Chronic heart disease (CHD) remains a leading cause of global mortality.
- Effective interventions are crucial for managing CHD progression.
- Omega-3 fatty acids (FAs) show promise due to anti-inflammatory and endothelial-protective effects.
Purpose of the Study:
- To evaluate the efficacy of omega-3 FA supplementation in patients with CHD.
- To assess the impact of omega-3 FAs on inflammation markers.
- To determine the effect on endothelial function in CHD patients.
Main Methods:
- Systematic literature search of international databases (Web of Science, PubMed, Embase, Scopus).
- Meta-analysis using random and fixed-effects models (STATA v15).
- Inclusion of 13 clinical trials with 853 participants (406 cases, 447 controls).
Main Results:
- Omega-3 FA supplementation significantly reduced IL-6, hs-CRP, and TNF-α levels.
- A significant increase in flow-mediated dilation (FMD) was observed with omega-3 supplementation (0.34%).
- Pooled analysis demonstrated statistically significant improvements in key inflammatory and endothelial markers.
Conclusions:
- Omega-3 fatty acid supplementation demonstrates therapeutic potential in managing CHD.
- Supplementation effectively modulates inflammation and improves endothelial dysfunction in CHD patients.
- Findings support the use of omega-3 FAs as an adjunct therapy for chronic heart disease.
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