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Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Decreased Body Temperature

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Updated: Jun 24, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

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Published on: September 27, 2019

Interventions for postburn pruritus.

Sarthak Sinha¹, Vincent A Gabriel², Rohit K Arora¹

¹Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Canada.

The Cochrane Database of Systematic Reviews

|June 5, 2024

Summary

Postburn pruritus (itch) is common, but evidence for 21 interventions is of moderate to low certainty. Some treatments like doxepin cream and massage show potential benefits, but more high-quality research is needed.

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Area of Science:

Dermatology
Evidence-Based Medicine
Clinical Trials

Background:

Postburn pruritus (itch) is a frequent and distressing symptom following burn injuries.
Current treatments for postburn pruritus lack clear evidence of effectiveness.
This review assesses interventions for managing postburn pruritus in various settings.

Approach:

Conducted a systematic review of 25 randomized controlled trials (RCTs) involving 1166 participants.
Included interventions encompassed neuromodulatory agents, topical therapies, physical modalities, laser scar revision, electrical stimulation, and other therapies.
Assessed the certainty of evidence using GRADE methodology.

Key Points:

Neuromodulatory agents (doxepin, gabapentin, pregabalin, ondansetron) showed low to moderate certainty evidence for reducing pruritus.
Topical enalapril ointment demonstrated moderate certainty of reducing pruritus.
Physical modalities like massage and extracorporeal shock wave therapy (ESWT) showed low certainty evidence for pruritus and pain reduction.
Laser scar revision had moderate certainty evidence for reducing pruritus and pain.
Most studies were small and at high risk of bias, with incomplete reporting of secondary outcomes.

Conclusions:

The evidence for 21 interventions for postburn pruritus is of moderate to low certainty.
While some interventions show promise, the quality of evidence is limited by study size and risk of bias.
Practitioners should carefully consider the applicability of existing moderate-certainty evidence for their patients.