Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary albumin excretion after donor nephrectomy.

J A Bertolatus, M A Friedlander, C Scheidt

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |March 1, 1985
    PubMed
    Summary

    Unilateral nephrectomy in humans caused a slight rise in blood pressure but did not lead to kidney injury from hyperfiltration within three years. Albuminuria did not persist after initial transient elevations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Purified Human Pancreatic Islets, CIT Culture Media with Lisofylline or Exenatide.

    CellR4-- repair, replacement, regeneration, & reprogramming·2019
    Same author

    Regional variability in liver waiting list removals causes false ascertainment of waiting list deaths.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013
    Same author

    OPTN policy regarding prioritization of patients with hepatopulmonary syndrome: does it provide equitable organ allocation?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2008
    Same author

    Short- and long-term outcomes with the use of kidneys and livers donated after cardiac death.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006
    Same author

    Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective.

    Kidney international·2006
    Same author

    Biological activity of plant extracts: novel analgesic drugs.

    Expert opinion on emerging drugs·2005

    Area of Science:

    • Nephrology
    • Transplant Surgery
    • Physiology

    Background:

    • Unilateral nephrectomy in animals causes hyperfiltration, hypertension, and glomerular sclerosis.
    • Microalbuminuria predicts severe renal disease in diabetics.
    • The long-term effects of unilateral nephrectomy on human kidney function are not fully understood.

    Purpose of the Study:

    • To investigate whether unilateral nephrectomy in humans initiates a similar sequence of compensatory hyperfiltration, hypertension, and renal injury as observed in animal models.
    • To assess changes in urinary albumin excretion, total protein excretion, creatinine clearance, and blood pressure following donor nephrectomy.

    Main Methods:

    • Prospective study of 22 kidney transplant donors before and up to 3 years after unilateral nephrectomy.

    Related Experiment Videos

  • Measurement of urinary albumin excretion (UalbV) using ELISA, total protein excretion (UprotV), and creatinine clearance (Ccreat).
  • Regular monitoring of blood pressure.

    • Main Results:

    • Creatinine clearance decreased to 68% of pre-nephrectomy values, indicating a 33% rise in single nephron filtration rate.
    • Transient elevations in albumin and total protein excretion were observed one week post-surgery, returning to baseline thereafter.
    • A slight but significant increase in systolic and diastolic blood pressure was noted by two years post-surgery.

    Conclusions:

    • Unilateral nephrectomy in humans leads to compensatory hyperfiltration and a modest increase in blood pressure.
    • Despite hyperfiltration, no evidence of glomerular injury was observed within the 3-year follow-up period.
    • Transient albuminuria post-nephrectomy does not appear to predict long-term renal damage in this cohort.