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COPD With Lung Cancer Among Older United States Adults: Prevalence, Diagnostic Timeliness, and Association With
Eman M Metwally1,2, Jennifer L Lund1,2, M Bradley Drummond3
1Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Chronic Obstructive Pulmonary Diseases (Miami, Fla.)
|June 5, 2024
Summary
Most lung cancer patients have chronic obstructive pulmonary disease (COPD), but many are diagnosed late. An earlier COPD diagnosis may aid early lung cancer detection.
Area of Science:
- Pulmonary Medicine
- Oncology
- Epidemiology
Background:
- Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in lung cancer patients, impacting prognosis.
- Underdiagnosis of COPD is common in this patient population.
Purpose of the Study:
- To determine COPD prevalence in U.S. lung cancer patients.
- To analyze the timing of COPD diagnosis relative to lung cancer diagnosis.
- To investigate the association between early COPD diagnosis and lung cancer stage, considering sociodemographic factors.
Main Methods:
- Analysis of the Medicare-linked Surveillance, Epidemiology, and End Results database (2008-2017).
- Inclusion of patients aged 68+ with lung cancer.
- COPD diagnosis timing classified as 'preexisting' (>3 months prior) or 'concurrent' (+/-3 months) to lung cancer diagnosis.
Main Results:
- 73.5% of 159,542 lung cancer patients had COPD.
- 34.4% of COPD patients received a diagnosis concurrently with their lung cancer.
- Preexisting COPD was associated with early-stage lung cancer (PR=1.27; 95% CI=1.23-1.30), particularly in males, non-Hispanic Black, and Hispanic individuals.
Conclusions:
- A high prevalence of COPD exists among lung cancer patients.
- Many patients receive COPD diagnoses concurrently with lung cancer.
- Earlier diagnosis of COPD may facilitate earlier detection of lung cancer.
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