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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Pathophysiology of Diabetes01:20

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  11. Association Of Low Carbohydrate Diet Score With The Risk Of Type 2 Diabetes In An Australian Population: A Longitudinal Study.
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  11. Association Of Low Carbohydrate Diet Score With The Risk Of Type 2 Diabetes In An Australian Population: A Longitudinal Study.

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Association of low carbohydrate diet score with the risk of type 2 diabetes in an Australian population: A longitudinal study.

Robel Hussen Kabthymer1, Md Nazmul Karim2, Catherine Itsiopoulos3

  • 1Department of Medicine, School of Clinical Sciences, Monash University, 3168, Melbourne, VIC, Australia.

Diabetes & Metabolic Syndrome
|June 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

A high low carbohydrate diet score (LCD) was linked to increased type 2 diabetes (T2D) risk. This association was primarily explained by obesity, specifically body mass index (BMI).

Keywords:
Carbohydrate restrictionCohortHigh fat dietLow carbohydrate diet

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Area of Science:

  • Nutritional Epidemiology
  • Metabolic Disease Research

Background:

  • Dietary patterns significantly influence metabolic health and the risk of developing type 2 diabetes (T2D).
  • Understanding the specific impact of carbohydrate intake on T2D incidence is crucial for public health recommendations.

Purpose of the Study:

  • To investigate the association between a low carbohydrate diet score (LCD) and the incidence of type 2 diabetes (T2D).
  • To explore the mediating role of adiposity, specifically body mass index (BMI) and waist-to-hip ratio (WHR), in this relationship.

Main Methods:

  • Analysis of data from 39,185 participants in the Melbourne Collaborative Cohort Study (MCCS).
  • Calculation of LCD score based on baseline energy intake from carbohydrates, fat, and protein.
  • Assessment of T2D incidence using modified Poisson regression, adjusted for confounders, and mediation analysis for adiposity.
Type 2 diabetes

Main Results:

  • A higher LCD score, indicating lower carbohydrate intake, was positively associated with an increased risk of T2D (p for trend = 0.001).
  • Participants in the highest quintile of LCD (38% energy from carbohydrates) had a 20% higher risk of T2D compared to the lowest quintile (55% energy from carbohydrates).
  • The association between LCD and T2D risk was eliminated after adjusting for BMI and WHR, with BMI mediating 76% of the effect.

Conclusions:

  • Consuming a low carbohydrate diet, as indicated by a high LCD score, may elevate the risk of type 2 diabetes.
  • Obesity, particularly BMI, largely explains the link between low carbohydrate diets and increased T2D risk.
  • Further research, including clinical trials, is warranted to fully understand the impact of low carbohydrate diets on T2D.