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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

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Non-invasive Assessment of Microvascular and Endothelial Function
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Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.

Serena Zanelli1,2, Davide Agnoletti3,4,5, Jordi Alastruey6

  • 1Laboratoire Analyse, Géométrie et Applications, Université Sorbonne Paris Nord, Paris, France.

Physiological Measurement
|June 5, 2024
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Vascular ageing, the natural deterioration of arteries, is increasingly recognized as a cardiovascular risk marker. Developing technologies for its assessment is crucial for clinical practice and disease management.

Keywords:
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Area of Science:

  • Cardiovascular research
  • Biomedical engineering
  • Gerontology

Background:

  • Vascular ageing is the age-related decline in arterial structure and function.
  • This process can be exacerbated by various diseases.
  • Current measurements of vascular ageing show promise as cardiovascular risk indicators.

Purpose of the Study:

  • To outline the current state of technologies for assessing vascular ageing.
  • To identify challenges in the development and clinical integration of these technologies.
  • To propose future research directions for advancing vascular ageing assessment.

Main Methods:

  • This roadmap synthesizes expert opinions and current literature on vascular ageing assessment.
  • It covers measurement technologies, the development pipeline, and clinical applications.
  • Expert discussions highlight challenges and future research needs.

Main Results:

  • Technologies for measuring vascular ageing are advancing but not yet standard clinical practice.
  • Key aspects discussed include measurement technologies, development pipelines, and clinical utility.
  • Significant challenges remain in translating these technologies into routine healthcare.

Conclusions:

  • Routine assessment of vascular ageing holds potential for improved cardiovascular disease diagnosis, prognosis, and treatment guidance.
  • Further technological development and validation are necessary for clinical implementation.
  • Addressing identified challenges will facilitate the integration of vascular ageing assessment into standard medical care.