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Related Experiment Video

Updated: Jun 24, 2025

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

109

Prognostic and clinicopathological value of Ki-67 in patients with oesophageal squamous cell carcinoma: a systematic

Yanyan Wang1, Menglu Dai2, Xu Chen3

  • 1Department of Pathology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.

BMJ Open
|June 5, 2024
PubMed
Summary
This summary is machine-generated.

High Ki-67 expression indicates a poor prognosis for esophageal squamous cell carcinoma (ESCC) patients, impacting overall survival and disease-free survival. A threshold of over 30% Ki-67 is particularly significant for predicting outcomes.

Keywords:
Adult oncologyAdult pathologyEPIDEMIOLOGYGastrointestinal tumoursMeta-AnalysisOesophageal disease

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Area of Science:

  • Oncology
  • Molecular Pathology

Background:

  • Ki-67 expression is a known proliferation marker.
  • Previous studies on Ki-67 and esophageal squamous cell carcinoma (ESCC) prognosis yielded inconsistent results.
  • A definitive prognostic value of Ki-67 in ESCC requires clarification.

Purpose of the Study:

  • To conduct a meta-analysis to precisely determine the prognostic value of Ki-67 in ESCC.
  • To evaluate the association between Ki-67 expression and overall survival (OS) and disease-free survival (DFS) in ESCC patients.

Main Methods:

  • Systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library until September 2023.
  • Meta-analysis of 11 studies including 1124 patients using random-effects or fixed-effects models based on heterogeneity.
  • Calculation of pooled Hazard Ratios (HRs) and Odds Ratios (ORs) with 95% Confidence Intervals (CIs).

Main Results:

  • Increased Ki-67 expression was significantly associated with poor OS (HR 1.62, p=0.006) and DFS (HR 1.72, p=0.002) in ESCC.
  • Subgroup analysis indicated that a Ki-67 threshold >30% strongly predicted OS and DFS.
  • No significant association was found between Ki-67 and clinicopathological features like sex, T stage, N stage, TNM stage, differentiation, or location.

Conclusions:

  • High Ki-67 expression is a significant predictor of poor prognosis in ESCC patients.
  • Ki-67, particularly at levels >30%, serves as a reliable prognostic indicator for OS and DFS in ESCC.
  • Further validation of Ki-67 as a prognostic biomarker in ESCC is warranted.