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Related Experiment Video

Updated: Jun 24, 2025

Subcutaneous Neurotrophin 4 Infusion Using Osmotic Pumps or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles
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Patient-Reported Outcomes after False Vocal Folds Injections for Adductor Spasmodic Dysphonia.

Deirdre Larsen1, Michael Olejniczak2, Yann P Kerevel3

  • 1Department of Communication Sciences and Disorders, Louisiana State University, Baton Rouge, Louisiana; Our Lady of the Lake, The Voice Center, Baton Rouge, Louisiana.

Journal of Voice : Official Journal of the Voice Foundation
|June 5, 2024
PubMed
Summary
This summary is machine-generated.

False vocal fold (FVF) or simultaneous FVF with thyroarytenoid (FVF+TA) Botox® injections offer comparable treatment effects to standard TA injections for adductor spasmodic dysphonia. Patient-reported outcomes can guide the choice between FVF and FVF+TA injections.

Keywords:
Adductor spasmodic dysphoniaBotulinum toxinFalse vocal folds injectionVentricular folds

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Area of Science:

  • Laryngology
  • Neurology
  • Otolaryngology

Background:

  • Adductor spasmodic dysphonia (ADSD) is a chronic neurological voice disorder.
  • Botulinum toxin type A (BoNT-A) injections are a primary treatment for ADSD.
  • Standard treatment involves thyroarytenoid (TA) muscle injections.

Purpose of the Study:

  • To compare the efficacy of false vocal fold (FVF) or simultaneous FVF with TA (FVF+TA) Botox® injections against standard TA injections for ADSD.
  • To evaluate patient-reported outcomes influencing the decision to use FVF or FVF+TA injections.

Main Methods:

  • Retrospective chart review of 20 ADSD patients treated between 2005-2018.
  • Patients initially received TA injections, then transitioned to FVF (n=7), FVF+TA (n=6), or continued TA (n=7) based on response.
  • Comparison of injection dosage, cycle duration, voice quality duration, breathiness, and choking between groups.

Main Results:

  • FVF injections showed similar voice quality, breathiness, and choking duration compared to TA injections.
  • FVF+TA injections demonstrated similar injection cycle duration, voice quality, breathiness, and choking duration to TA injections post-treatment.
  • Both FVF and FVF+TA injections led to increased duration of injection cycles and improved voice quality within their respective groups.

Conclusions:

  • FVF injections provide comparable voice outcomes to TA injections, with shorter injection cycles potentially benefiting some patients.
  • FVF+TA injections offer similar voice and cycle duration outcomes to TA injections, suitable for patients prioritizing longer injection cycles and voice quality.
  • Patient-reported outcomes and tolerance for adverse events are key factors in selecting FVF or FVF+TA injections for ADSD management.