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  1. Home
  3. Variations In Germ Cell Tumor Histology By Age And Implications For Cancer-specific Survival Among Pediatric And Adult Males: A Population-based Study.
  1. Home
  3. Variations In Germ Cell Tumor Histology By Age And Implications For Cancer-specific Survival Among Pediatric And Adult Males: A Population-based Study.

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Variations in germ cell tumor histology by age and implications for cancer-specific survival among pediatric and

J Bradley Mason1, Arnav Srivastava2, Nicholas J Lanzotti3

  • 1Department of Urology, MedStar Georgetown University Hospital, Washington, DC.

Urologic Oncology
|June 5, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Cancer-specific survivalChoriocarcinomaGerm cell tumorHistologyNonseminomaSeminomaTeratomaYolk sac tumor

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Germ cell tumor (GCT) histology differs by age in males, with distinct survival outcomes. Pediatric patients with non-seminomatous GCT (NSGCT) showed better survival than adults.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Cancer Epidemiology

Background:

  • Germ cell tumors (GCTs) are the most common solid tumors in young males.
  • Limited data exists on age-related differences in GCT histology and their impact on survival.

Purpose of the Study:

  • To quantify differences in GCT histology between male children and adults.
  • To evaluate the implications of these differences on cancer-specific survival (CSS).

Main Methods:

  • Utilized Surveillance,
  • Epidemiology, and End Results (SEER) cancer registries (1988-2016).
  • Analyzed demographic and tumor characteristics for male patients aged 0-40 diagnosed with GCT, comparing histology distributions across age groups (0-4, 12-18, 19-40 years).
  • Assessed CSS using multivariable Cox proportional hazards regression models.

Main Results:

  • Identified 27,204 male patients; 5.7% were pediatric (0-18 years).
  • Histology varied by age: yolk sac tumors and teratoma predominated in ages 0-4; mixed GCT in ages 12-18; seminoma in ages 19-40.
  • Adults had similar CSS for seminoma but worse CSS for non-seminomatous GCT (NSGCT) compared to pediatric patients.
  • Choriocarcinoma and yolk sac tumors showed the worst prognosis in both age groups.

Conclusions:

  • GCT histology significantly varies by age in male patients.
  • Pediatric patients with NSGCT demonstrated superior CSS compared to adult counterparts.
  • Age, tumor stage, and histology are critical determinants of CSS in both pediatric and adult GCT populations.