The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers
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View abstract on PubMed
Summary
This summary is machine-generated.Targeted prostate cancer screening for BRCA1/BRCA2 gene carriers does not negatively impact psychosocial health. This longitudinal study found no adverse effects on quality of life in high-risk men undergoing annual screening.
Area Of Science
- Oncology
- Genetics
- Psychosocial Health
Background
- Prostate cancer (PrCa) screening is increasingly targeted towards high-risk populations.
- Men with germline pathogenic variants (GPVs) in BRCA1 or BRCA2 genes have an elevated risk of PrCa.
- Understanding the psychosocial impact of targeted screening is crucial for patient well-being.
Purpose Of The Study
- To evaluate the long-term psychosocial outcomes of a targeted PrCa screening program.
- To assess the impact of annual screening on anxiety, depression, and quality of life in men with BRCA1/BRCA2 GPVs and controls.
- To determine if targeted screening affects cancer worry and risk perception.
Main Methods
- Longitudinal psychosocial questionnaires administered annually for at least 5 years to 760 participants in the IMPACT study.
- Participants included BRCA1 (n=207) and BRCA2 (n=265) GPV carriers and non-carrier controls (n=288).
- Measures included general and cancer-specific anxiety, depression, health-related quality of life, cancer worry, risk perception, and knowledge.
Main Results
- No evidence of clinically significant general or cancer-specific distress or poor quality of life in the overall cohort.
- Control group reported significantly less PrCa worry than carriers, but all scores were low and within population norms.
- BRCA2 carriers with high PSA levels showed a small increase in PrCa and PSA-specific anxiety.
Conclusions
- Annual PSA-based screening for BRCA1/BRCA2 carriers is not associated with adverse psychosocial effects.
- Targeted screening programs can be implemented without negatively impacting participants' mental health or quality of life.
- Findings support the safety of intensive screening protocols for genetically predisposed individuals.
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