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Updated: Jun 24, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Published on: August 16, 2019

Sequential immunotherapy: towards cures for autoimmunity.

Francisco Ramírez-Valle¹, Joseph C Maranville², Sophie Roy²

¹Bristol Myers Squibb, New York, NY, USA. Francisco.Ramirez-Valle@bms.com.

Nature Reviews. Drug Discovery

|June 5, 2024

Summary

This summary is machine-generated.

Sequential immunotherapy offers a new strategy to potentially cure autoimmune diseases by controlling inflammation, resetting the immune system, and restoring immune homeostasis. This approach aims for long-term remission and improved patient outcomes.

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Last Updated: Jun 24, 2025

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Published on: August 16, 2019

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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Area of Science:

Immunology
Autoimmune Diseases
Therapeutics

Background:

Current autoimmune disease treatments often fail to cure and carry infection risks due to broad immune suppression.
Advances in understanding autoimmune disease etiology and novel therapies like CAR T-cell treatments suggest potential for immune system restoration.

Purpose of the Study:

To propose a 'sequential immunotherapy' framework to modulate the immune system for potential autoimmune disease cure.
To outline a multi-step approach for re-establishing immune homeostasis and achieving long-term remission.

Main Methods:

A three-step framework: 1. Control inflammation. 2. Reset the immune system by eliminating pathogenic memory cells. 3. Promote immune homeostasis with regulatory agents and tissue repair.
Discussion of existing and developing drugs for each step.
Emphasis on utilizing causal human biology for strategy development and patient stratification.

Main Results:

The proposed framework integrates existing and emerging therapeutic strategies.
Highlights the importance of precision medicine informed by human biology to tailor treatments for specific patient subsets.

Conclusions:

Sequential immunotherapy presents a promising framework for transforming autoimmune disease care.
This approach has the potential to achieve long-term remission or cure by precisely modulating the immune system.