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Functions of Thyroid Hormones01:18

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Synthesis and Regulation of Thyroid Hormones01:20

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Updated: Jun 24, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Thyroid function spectrum in Cushing's syndrome.

Peng Yu1,2, Haoyue Yuan1, Hong Chen3

  • 1Department of Endocrinology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Fenglin Road 180, Xuhui District, Shanghai, 200032, China.

BMC Endocrine Disorders
|June 5, 2024
PubMed
Summary
This summary is machine-generated.

Thyroid function is impaired in patients with Cushing's syndrome (CS), with abnormal thyroid hormone levels correlating with cortisol. Further research is needed to understand these physiological adaptations and pathological conditions.

Keywords:
Cushing’s syndromeDiagnosisEndocrine pathophysiologyThyroid dysfunction

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Area of Science:

  • Endocrinology
  • Metabolic Disorders

Background:

  • Thyroid disorders are observed in patients with hypercortisolism.
  • Endogenous Cushing's syndrome (CS) can exacerbate metabolic complications.

Purpose of the Study:

  • To investigate thyroid function in patients with CS.
  • To determine the relationship between thyroid function and cortisol levels in CS patients.

Main Methods:

  • Cross-sectional study of 129 CS patients (2016-2019).
  • Collected demographic, medical history, and laboratory data.
  • Performed a meta-analysis on thyroid dysfunction prevalence in CS.

Main Results:

  • 48.6% had low triiodothyronine (TT3), 27.9% low thyroxine (TT4), 24.6% low free T3 (FT3), 27.7% low free T4 (FT4), and 6.2% low thyroid-stimulating hormone (TSH).
  • Clinical CS showed more thyroid suppression than subclinical CS.
  • Meta-analysis revealed 22.7% central hypothyroidism in 528 CS patients across nine studies.

Conclusions:

  • Thyroid hormone levels are significantly correlated with cortisol levels in CS patients.
  • Thyroid function is impaired in individuals with CS.
  • Further investigation is required to elucidate the physiological adaptations and pathological mechanisms involved.