Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Types of RNA

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Probing the <i>C</i> <sub>3</sub> symmetry of gramicidin S.

RSC chemical biology·2026

Same author

Knowledge preservation in the era of big science and AI: strategies for sustainable scientific research.

Nature communications·2026

Same author

Sequencing peptides by reversing translation.

Nature biotechnology·2026

Same author

Structural basis of supercoiling-induced CRISPR-Cas9 off-target activity.

Nature·2026

Same author

Synthetic data-driven deep learning for label-free autonomous atomic force microscopy.

Nature communications·2026

Same author

Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis.

Nature communications·2025

Same journal

Cell Membrane-Engineered FePDA Nanoparticles Integrate Ferroptosis and Antitumor Immunity.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Finding the Perfect Match: Investigation of 1,2-Diketone-Based Materials for Use as Cathode Active Material in Rechargeable Magnesium Batteries.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Stabilization of Cu Species in UiO-66 Metal-Organic Framework for CO<sub>2</sub>-to-Methanol: Insights From Operando X-ray and Electron Microscopy Studies.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Multifunctional Nanodiamond Conjugate With a Tumor-Specific EGFR-Targeting Peptide and Photoactivated CO Release for Improved Therapeutic Efficacy in Head and Neck Cancers.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Multifunctional Self-Bonding Biocomposites Enabled by Uniform Dispersion of Carbon Nanotube via In Situ Lignin and Multiple Noncovalent Bonds.

Small (Weinheim an der Bergstrasse, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 24, 2025

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

Published on: March 17, 2023

Lipidated DNA Nanostructures Target and Rupture Bacterial Membranes.

Isabel D Bennett^1,2, Jonathan R Burns³, Maxim G Ryadnov^4,5

¹London Centre for Nanotechnology, University College London, 17-19 Gordon Street, London, WC1H 0AH, United Kingdom.

Small (Weinheim an Der Bergstrasse, Germany)

|June 6, 2024

Summary

This summary is machine-generated.

Cholesterol-tagged DNA nanostructures selectively kill bacteria by disrupting their membranes. This discovery offers a novel strategy against antimicrobial resistance using targeted nanomaterial design.

Keywords:

DNA nanotechnology DNA origami antimicrobial resistance atomic force microscopy bacteria

More Related Videos

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

Related Experiment Videos

Last Updated: Jun 24, 2025

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture

Published on: March 17, 2023

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

Area of Science:

Biomedical chemistry
Nanotechnology
Microbiology

Background:

Supramolecular nanostructures can be engineered for biomedical applications.
Bacterial membranes differ in cholesterol content from eukaryotic membranes.

Purpose of the Study:

To investigate cholesterol-tagged DNA nanostructures as antibacterial agents.
To determine the mechanism of bacterial membrane disruption by these nanostructures.

Main Methods:

Synthesis of cholesterol-modified DNA nanostructures.
Testing nanostructure binding affinity to bacterial and eukaryotic membranes.
Microscopy and biochemical assays to elucidate the cell death mechanism.

Main Results:

Lipidated DNA nanostructures selectively bind to cholesterol-free bacterial membranes.
Nanostructures induce bacterial cell death through membrane rupture.
Bacterial killing is mediated by clusters of nanostructures adhering to the membrane.

Conclusions:

Cholesterol-tagged DNA nanostructures represent a promising antibacterial strategy.
The findings suggest a mechanism of membrane disruption independent of traditional pore formation.
This research could lead to new antibacterial agents to combat antimicrobial resistance.